Stepanov Oleg Alexeevich (junior researcher, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow)
Snezhkina Anastasiya Vladimirovna (PhD, researcher, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow)
Kiseleva Marina Viktorovna (MD, Dr. of Sci., head of department, National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow)
Golovyuk Alexander Leonidovich (MD, PhD, Vishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, Moscow.)
Pavlov Vladislav Sergeevich (PhD student, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow)
Kudryavtseva Anna Viktorovna (PhD, head of department, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow)
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Paraganglioma and pheochromocytoma are rare neuroendocrine tumors, characterized by variable metastatic potential. Identification of tumor aggressiveness markers on the early stages is an important task. Literature data analysis revealed that mutations in the SDHB gene, encoding succinate dehydrogenase subunit B, have the greatest prognostic significance. Mutations in FH, IDH1, IDH2, and MDH2 genes cause the similar disruptions and also associated with poor prognosis. Paragangliomas and pheochromocytomas can also be caused by other genetic disorders, but the list of markers and potential prognostic markers contains exactly the genes involved in the tricarboxylic acid cycle.
Keywords:paraganglioma, pheochromocytoma, molecular pathology, tumor progression, driver mutations, energy metabolism
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Citation link:
Stepanov O. A., Snezhkina A. V., Kiseleva M. V., Golovyuk A. L., Pavlov V. S., Kudryavtseva A. V. Mutations in genes involved in tricarboxylic acid cycle are associated with aggressiveness of paragangliomas and pheochromocytomas // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2019. -№2. -С. 105-111 |
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