DYNAMICS OF THE MAIN PARAMETERS OF FIBRIN IN PATIENTS WITH SEVERE FORMS OF ACUTE PANCREATITIS

Vasiltsova Natalia Aleksandrovna, Namokonov Evgeny Vladimirovich, Yashnov Alexey Alexandrovich

In 2024, 167,208 cases of acute pancreatitis were registered in the Russian Federation. In-hospital mortality for this disease is 2.99%, while postoperative mortality reaches 19.3%. Currently, various laboratory and instrumental diagnostic methods, as well as various assessment scales, are widely used to diagnose and assess the severity of patients with destructive pancreatitis and multiple organ failure. In this regard, the identification of laboratory biomarkers capable of recognizing destructive changes in pancreatic tissues in a short time (within the first 24 hours) is becoming an important task in the field of surgery. In this paper, the parameter of fibrin dynamics in patients with moderate and severe severity was studied. The conducted prospective study included the results of examination of 23 patients with severe and moderate acute pancreatitis, treated at the ChUZ "Clinical Hospital "RZhD-Medicine", Chita" from 2022 to 2024, aged 16 to 85 years. On the first day, the patient undergoes a clinical blood test, fibrin indicators are assessed by the "T2-T Thrombodynamics Analyzer (SL AT T2-T)" system. Statistical processing was carried out using the Statistica 21 software package. The study found a progressive increase in the fibrin dynamics parameter. Thus, with readings of Vst ≥ 48.70 ± 3.51 μm/min (p≤0.05), thrombosis and the development of necrotic changes in tissues are predicted; in patients with a severe degree, the average steady-state clot velocity is 55.46 ± 7.7 μm/min, and in patients with an average degree 41.85 ± 5.6 μm/min, which is 1.3 times less than in patients with a severe form (p≤0.05).

Keywords:acute pancreatitis, coagulogram, fibrinogen, pancreatic necrosis, diagnostics.