Shilo Polina Sergeevna (Oncologist
First Saint Petersburg State Medical University named after Academician I. P. Pavlov, LLC Clinic "Lakhta", Saint Petersburg, Russia
)
Makarkina Maria Leonidovna (Oncologist, PhD
Saint Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care, Oncology named after N. P. Napalkov
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Zakharenko Alexander Anatolyevich (Oncologist, MD, Professor, Head of the Oncology Department of the Faculty of Postgraduate Studies,
First Saint Petersburg State Medical University named after Academician I. P. Pavlov
)
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In recent decades, the approach to the choice of therapy for cancer patients has changed from empirical to individualized, based on the molecular profile of the tumor. This study aims to analyze the efficacy of molecularly targeted therapy in patients with advanced solid tumors in real clinical practice. The retrospective single-center study analyzed data from 104 patients who underwent comprehensive genomic profiling at Lakhta Clinic from 2019 to 2023. Successful testing was performed in 87 patients (83.7%), among which breast cancer, colorectal cancer and pancreatic cancer were predominant. Mutation load was determined in 57 patients, with a median of 4 mutations per megabase. High mutational load (≥10 mutations/megabase) was identified in 6 patients. The results of this study indicate the importance of using targeted sequencing panels to optimize cancer treatment.
Keywords:molecularly targeted therapy, solid tumors, genomic profiling, mutational load, targeted sequencing, oncology, individualized approach, clinical practice
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Read the full article …
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Citation link:
Shilo P. S., Makarkina M. L., Zakharenko A. A. COMPREHENSIVE GENOMIC PROFILING AND MOLECULARLY TARGETED THERAPY IN PATIENTS WITH ADVANCED SOLID TUMORS: EVIDENCE FROM REAL CLINICAL PRACTICE // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№02/2. -С. 223-228 DOI 10.37882/2223-2966.2025.02-2.39 |
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