THE IMPACT OF INHALED CORTICOSTEROIDS ON THE ORAL MUCOSA IN PATIENTS WITH TUBERCULOSIS

Khanaliev V., Guseynova S., Abakarov T., Budaichiev G.

Inhaled corticosteroids (ICS) are widely used for the treatment of respiratory diseases; however, their impact on the oral mucosa in patients with active tuberculosis remains insufficiently studied. This study assessed the effects of ICS on the oral mucosa in 120 patients divided into two groups: the main group (receiving ICS) and the control group. The results revealed significant alterations in the oral mucosa in the main group, including clinical manifestations (hyperemia, atrophy, erosions, candidiasis), microbiological dysbiosis, histological changes in the epithelium, and reduced protective properties of saliva. A significant correlation was established between the duration of ICS therapy and the severity of mucosal changes. These findings highlight the need for preventive and corrective measures to mitigate the side effects of ICS in this patient population.

Keywords:inhaled corticosteroids, tuberculosis, oral mucosa, dysbiosis, biochemical changes, histological analysis, candidiasis