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Dual blockade of the renin-angiotensin-aldosterone system in order nefroprotektsii in patients with diabetic nephropathy

Amirova Asel Adilkyzy  (physician assistant 2nd Department of Internal Medicine Therapeutic training clinic Azerbaijan Medical University )

Diabetic nephropathy (DN) is a clinical syndrome characterized by microalbuminuria (MAU) or proteinuria, progressive decline in glomerular filtration rate (GFR), the development or strengthening of arterial hypertension (AH). It is known that the impaired function of the renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathogenesis of chronic kidney disease. Due to the constant stimulation from the RAAS, the pressure increase in the glomerular capillaries, which is accompanied by oxidative stress and activation of pro-inflammatory signaling pathways. These reactions lead to glomerular hypertrophy that occurs in the early stages of diabetic nephropathy, and initiates the beginning Profibrotic stage.

Keywords:block, nephropathy, diabetes, aldosterone, nefroprotektsiya.
 

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Citation link:
Amirova A. A. Dual blockade of the renin-angiotensin-aldosterone system in order nefroprotektsii in patients with diabetic nephropathy // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2016. -№04. -С. 64-70
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