Morfocitometric diagnosis of pathology of a fetoplacental complex

Mironov Alexey Valentinovich

Purpose: determination of diagnostic value of a morphometry of the circulating endotheliocytes in prediction of the complicated course of pregnancy. Research techniques. At 163 pregnant women selected by a kogortny method in the I trimester the computer morphometry of circulating endotheliocytes of peripheral blood is carried out. Depending on effective diameter of the circulating endotheliocytes 3 groups of patients are created. The research of a course of pregnancy and a perinatal outcome taking into account results of morfocitometric diagnosis of endothelial dysfunction is conducted. Results. On somatic pathology the studied groups were comparable. The menacing spontaneous abortion is diagnosed with a frequency of 24,3% in the I group, 44,4% - in the II group, and 90,9% - in the III group. (p<0,001; t=10,2). Frequency of a fetoplacental failure was 10,8% in the I group, 31,1% - in the II group (p<0,05; t=2,6) and 70,5% - in the III group (p<0,001; t=7,7). A preeclampsia developed at 10,8% of women of the I group, 15,6% - the II group, and 61,4% - the III group (p<0,001; t=6,2). Assessment on a scale Apgar in the fifth minute less than 8 points at newborns: 2,7% in the I group, 26,7% - in the II group (p<0,001; t=3,5) and 13,6% - in the III group (p<0,05; t=2,1). Conclusions. The computer morphometry of the circulating endotheliocytes can be a recent trend of early diagnostics of violation of a fetoplacental complex.

Keywords:pregnancy, endothelium, morphometry.