The role of C-terminal segment of the tumor suppressor р14ARF in the activation of nonselective autophagy in human cells

Soloviev Alexander, Budina Anna, Anaschenkova Tatiana

The article presents data on the determination of the area of the tumor suppressor protein ARF, responsible for the activation of non-selective autophagy in human cells. In experiments on osteosarcoma cells it was shown that activation of nonselective ARF-mediated autophagy occurs with the participation of C-terminal portion of p14ARF protein. The deletion of the C-terminal area disrupts ARF-mediated autophagy in tumor cells.

Keywords:autophagy, tumor suppressor, ARF, deletion.