And prognostic signifi cance of microsatellite instability in patients with cancer endometry

Сham Karine Gurgenovna, Raskin Grigory Aleksandrovich, Vinokurov Vladimir Leonidovich, Gelbutovskaya Svetlana Mishailovna, Lisyanskaya Alla Sergeevna

In this work, the frequency of occurrence of unrepaired DNA nucleotide repair (dMMR) in endometrioid adenocarcinoma of the uterus (31%) was determined. For the first time, a feature was found that with common forms of endometrial adenocarcinoma of the endometrium, the average age of patients with loss of MSH2 / MSH6 gene expression is less than the average age of patients with loss of PMS2 / MLH1 expression, regardless of the prevalence of the main pathological process (42.3 ± 4.15 and 60, 0 ± 1.62 years, respectively, p <0.05). The prognostically more favorable course of the common form of endometrial endometrial adenocarcinoma was found to be associated with impaired repair of unpaired DNA nucleotides: the average life expectancy of patients with dMMR was 43.9 ± 3.51 months, without dMMR - 30.0 ± 3.27 months (p <0.05). It is noted that immunohistochemistry is a more sensitive method in comparison with polymerase chain reaction for the selection of patients with endometrial adenocarcinoma of the endometrium, which have a high probability of a response to immunotherapy according to the dMMR / MSI-H criterion (31% according to IHC and 23% according to polymerase chain reaction).

Keywords:uterine cancer, endometrial adenocarcinoma, genes of mismatch repair systems (MRR), microsatellite instability (MSI)