Change of indexes of vegetative regulation of cardiac activity in patients with systemic scleroderma at the time of treatment with calcium antagonist and angiotensin-converting enzyme inhibitor

Lazareva N. V.

the dynamics of heart rate variability in 60 patients with systemic scleroderma receiving niphedipine or enalapril on the background of basic therapy was studied. Against the background of treatment with enalapril, there is a decrease in the activity of the sympathetic nervous system. Significantly increased indicators of autonomic regulation of the heart, characterizing the activity of the sympathetic nervous system (LF, LF/HF) on the background of therapy with niphedipine. At the same time, indicators reflecting the contribution of the parasympathetic part of the autonomic nervous system decreased. In patients receiving only basic therapy, there were no significant changes in the indicators.

Keywords:systemic scleroderma, cardiac rhythm variability, vegetative nervous system, vegetative regulation.