Egorova A. (Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, Kazan)
Kalinnikova T. (Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, Kazan)
Kolsanova R. (Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, Kazan)
Gainutdinov M. (Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, Kazan)
Shagidullin R. (Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, Kazan)
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In experiments with soil nematodes C. elegans it was shown that short-term exposition of nematodes to Cu2+ and Cd2+ ions (30–60 μM) caused sensitization of nicotinic acetylcholine receptors. This sensitization revealed in the increase of the sensitivity of swimming, as induced by mechanical stimulus, to agonist of nicotinic receptors levamisole and was a consequence of activation of nociceptive sensory neurons by Cu2+ and Cd2+ ions. Sensitization of nicotinic cholinergic receptors caused activation of cholinergic transmission, which revealed in rise of sensitivity of nematodes behavior to partial inhibition of acetylcholinesterase by aldicarb.
Keywords:Caenorhabditis elegans, nicotinic acetylcholine receptors, copper and cadmium ions, behavior
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Citation link:
Egorova A. , Kalinnikova T. , Kolsanova R. , Gainutdinov M. , Shagidullin R. Sensitization of nicotinic acetylcholine receptors of soil nematode Caenorhabditis elegans Maupas by Cu2+ and Cd2+ ions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2019. -№3. -С. 19-24 |
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