Neuroautoimmune reactions are normal in patients with neuropathic forms

Arsakhanova Gayna Abdulaevna

Changes in the immune system are not only concomitant, which characterize the course of the disease, but also largely determine it. In some diseases of the CNS cellular elements of the brain, delay or demyelination of nerve fibers. The leading role in the development of these reactions is played by natural, or autoantibodies. They are produced by CD5-lymphocytes, the proportion of which is 20% of all B-cells of the body. Autoantibodies in more than 50% of cases are represented by immunoglobulins G, which are monospecific and epitopospecific in their antigenic orientation (they bind only to a part of the antigen protein molecule). Their affinity is 10-12 M. Normal values of the level of autoantibodies are called the "Golden mean". It is believed that autoantibodies and autoreactive lymphocytes create a profile of biochemical individuality of the organism. They form a system of homeostasis regulation at the molecular level, which coordinates processes by interacting with various antigenic targets. The synthesis of autoantibodies in early ontogenesis begins earlier than the synthesis of antibodies to foreign antigens and coincides with the most important stages of differentiation and morphogenesis.

Keywords:autoantibodies, neuroautoimmune reactions, lysosomal diseases, nervous system.