Allelic variants of DRD2 and COMT genes and antipsychotic-induced hyperprolactinemia in patients with schizophrenia

Paderina Diana Zakirovna, Tiguntsev Vladimir Vladimirovich, Stegniy Vladimir Nikolaevich

Hyperprolactinemia is a prevalent neuroendocrine side effect that occurs with pharmacotherapy of schizophrenia. The likelihood of developing hyperprolactinemia depends both on the pharmacological properties of the antipsychotic and on the individual sensitivity and genetic characteristics of the patient. The study examined the genes of the dopaminergic system, which can predict individual susceptibility to side effects caused by antipsychotics. It has been shown that the DRD2 and COMT genes are involved in the formation of the genetic component of the development of drug-induced hyperprolactinemia in patients with schizophrenia.

Keywords:genetics, pharmacogenetics, dopamine, COMT, schizophrenia, antipsychotics, hyperprolactinemia.