Endothelin — 1 gene Lys198Asn polymorphism and development of cardiovascular pathology (review)

Bebyakova Natalia Alexandrovna, Levitsky Sergey Nikolaevich, Shabalina Irina Alekseevna, Sumarokova Alina Vladimirovna, Kurochkina Ekaterina Leonidovna

The article presents the generalized data of foreign and domestic literature on the influence of the candidate gene endothelin-1, responsible for the synthesis of the most powerful vasoconstrictor endothelin-1, as well as the possible influence of the polymorphic variant Lys198Asn on the development of cardiovascular diseases. The identified associations between lys198asn polymorphism in the endothelin-1 gene and changes in the functioning of the cardiovascular system, in particular, with myocardial infarction, various cardiomyopathies and other diseases, were studied. To date, it has been established that polymorphism of the endothelin-1 gene is not always associated with the risk of cardiovascular diseases, often the results of studies are contradictory, which requires further study of the role of lys198asn polymorphism in the endothelin-1 gene as a genetic marker of changes in the cardiovascular system.

Keywords:genetic markers of cardiovascular diseases, polymorphism of endothelin-1 gene.