TNF-α role in the development of squamous cell carcinoma of the oral cavity and autoimmune diseases

Kosyreva Tamara Fedorovna, Katbeh Imad, Saneeva Lada Vladimirovna, Khasan Alexander

TNF-α is a pro-inflammatory cytokine involved in many cascading biochemical reactions of the immune response. It is produced by various immunocompetent cells, such as macrophages, activated monocytes, osteoclasts, as well as epithelial and endothelial cells. In modern medicine, there are two directions of development that contribute to the study of this cytokine. One of them is the use of TNF-α thymosin immunotherapy of oncological diseases, and the other is the use of TNF-α blockers to prevent the development of autoimmune, such as rheumatoid arthritis and ankylosing spondylitis [49]. We’ve conducted a study of various Russian and foreign sources, the analysis of which formed the hypothesis that the development of squamous cell carcinoma and autoimmune diseases are two sides of the same process: the body's immune response to the introduction of human papillomavirus. This assumption currently has no laboratory evidence. The purpose of the study was to examine various Russian and foreign sources regarding TNF-α and its role in the development of tumors of various origins and autoimmune diseases. Conclusion After a detailed study of the sources presented in this review, a hypothesis has been formed, that these processes are conjugate and occur simultaneously. Conducting scientific research on its basis, will allow a better understanding of the mechanisms of the immune response at a more subtle level, which will ultimately allow for a better selection of immunotherapy for both cancer patients and patients with autoimmune diseases.

Keywords:TNF-α; γ-interferon, squamous cell carcinoma; rheumatoid polyarthritis; cytokine therapy.