Application of the amniotic membrane in the treatment of diabetic foot ulcers review of literature

Rodin Oleg Vasilyevich, Kolosunin Ivan Aleksandrovich, Kozlov Sergey Aleksandrovich, Parkin Pavel Nikolaevich, Malysheva Anna Nikolaevna

A common complication of diabetes is diabetic foot ulcers. Ineffective treatment of this disease presents a serious medical dilemma for both patients and doctors, and creates a financial burden on the health care system. Despite the efforts of doctors, chronic diabetic foot ulcers are difficult or impossible to treat with standard medical care alone. For decades, the human amniotic membrane, consisting of the amnion and chorion, has shown high therapeutic potential, but only modern conservation methods have contributed to its wider use. Literature sources indicate that the amniotic membrane is effective in the treatment of chronic ulcers. The purpose of this review is to evaluate the effectiveness of using the amniotic membrane for the treatment of diabetic foot ulcers in conjunction with standard treatment. Conclusions: in General, a review of clinical studies showed that patients who received standard treatment in conjunction with the amniotic membrane, the healing rate of ulcers was higher than only with standard teraria. Additional tests are required to study the therapeutic effect of amnion / chorion membrane products (drugs or coatings).

Keywords:Diabetes mellitus, amniotic membrane, diabetic ulcers, standard therapy, wound care, growth factors.