Clinical, amnestic and morphofunctional parameters in patients with type 2 diabetes mellitus with neurodegeneration of retina

Ruchkin M. P., Makarevich E. S., Markelova E. V., Fedyashev G. A.

In this study we have included 40 patients with confirmed diagnosis of diabetes mellitus type 2 (main group) and 30 healthy volunteers (control group). All patients have been examined with optic coherence tomography RTVue-100 («Optovue», USA) and microperimetry «MAIA» (CenterVue, Italy). Analyze result of microperimetry we have revealed reliable (p=0,001) decrease of average sensitivity of retina in patients of the main group. Analyze results of OCT we have revealed reliable (p=0,01) difference in focal loss volume, in main group. These changes haven’t any dependence from clinical signs of diabetic retinopathy and this conclusion confirm that neurodegeneration begins earlier than vascular damage. In patients with diabetic neuropathy neurodegeneration of retina reveals more often.

Keywords:diabetes mellitus, diabetic retinopathy, neurodegeneration, microperimetry, optic coherence tomography.