Endothelial dysfunction and its role in the development of hepatic insufficiency with mechanical jaundi

Magomedov Khasae Magomedalievich

The review discusses in detail current issues on the issue of liver failure in obstructive jaundice, especially topical issues on the pathogenesis and role of endothelial dysfunction. Domestic and foreign authors in their studies confirm the key role of endothelium in the regulation of vascular hemostasis. The role of endothelium is the development of factors of inflammation and proliferation of vessels, participation in thrombosis and the balance between vasoconstriction and vasodilation. Endothelial dysfunction and damage in obstructive jaundice is manifested by a decrease in the concentration of nitric oxide in the blood, a sharp increase in the content of endothelin-1, the activity of the Wilibrand factor and a decrease in the number of desquamated endotheliocytes. The presence of hemolymphatic changes in endothelial dysfunction is one of the reasons for the development of liver failure, which is necessary for the early diagnosis of obstructive jaundice. In studies of domestic and foreign authors, there is no data on the role of endothelial dysfunction in the development of liver failure in obstructive jaundice. The identification of markers of endothelial dysfunction and their complications in obstructive jaundice is of great practical importance, as it allows an early diagnosis of liver failure. The purpose of this review is to present a generalized picture of recent advances devoted to the study of endothelial dysfunction, oxidative stress and the study of their role in endothelial dysfunction, oxidative stress in the pathogenesis of liver failure in obstructive jaundice.

Keywords:endothelial dysfunction, oxidative stress, nitric oxide, obstructive jaundice, liver failure.