The role of natural genetic variation in the increased incidence of breast and ovarian cancer

Bisultanova Zura Isanova, Dzhambetova Petimat Makhmudovna, Atsayeva Maret Makhmudovna, Dzhambetova Lydia Mahmudovna

A case-control study was conducted in 238 patients with diagnosed breast and ovarian cancer and in the control group (n=405) to assess the frequency of polymorphisms of the CYP1A1 (Ile462Val, MspI) and CYP1B1 (Val432Leu) genes and their role in the risk of developing tumors in the territory of the CR with a high level of ZNO. A comparative analysis of the frequency of minor alleles of the polymorphic variant of the CYP1A1A4889G gene in the Kursk region, which has the highest level of cancer incidence in Russia, and the results obtained in this study show a significantly significant difference in the frequency of homozygous minor g allele in the studied regions.

Keywords:Gene polymorphism, CYP1A1 (Ile462Val, MspI), CYP1B1 (Val432Leu), Chechen population.