Expression of neuroendocrine markers in endometrioid and serous ovarian cancer

Yagafarova K. R., Raskin G. A., Vinokurov V. L., Mukhina M. S.

This work analyzes the expression of neuroendocrine markers in endometrioid and serous ovarian cancer. The median Ki67 index was significantly higher in the group with endometrioid adenocarcinoma of ovarian cancer, amounting to 55 (20; 80), against the median value of 30 (10; 52.5) in the group of serous ovarian adenocarcinoma (p <0.05). A pronounced variability of ChrA was revealed, the maximum concentrations were recorded in patients with endometriodal adenocarcinoma (p <0.01). A positive value of INSM1 was found in 7 patients (9.59%), of which 5 patients with endometriotic ovarian adenocarcinoma (17.24% in the group) and 2 patients with serous adenocarcinoma (4.55% in the group). It was revealed that the expression of neuroendocrine markers: synaptophysin, chromogranin A, CD56 in ovarian adenocarcinomas is not a manifestation of the neuroendocrine nature of the tumor, since it is not associated with the expression of INSM1, but the expression of synaptophysin is a poor prognostic sign and is associated with worse survival.

Keywords:chromogranin A (ChrA), synaptophysin, CD 56, type 2 somatostatin, type 5 somatostatin, INSM1, ovarian cancer.