Advantages of multicompontnt antihypertensive therapy in patients with arterial hypertension

Koshurnikova Ekaterina Petrovna, Mishlanov Vitaly Yurievich, Sakhipov Marat Arturovich, Garaev Amir Timurovich, Kozlovskaya Marina Aleksandrovna

In the article the analysis of tax systems and the dynamics of small and medium business in Russia. The classification of taxes and fees, a comparison of special tax regimes: the simplified system of taxation and the single tax on imputed income. Main directions of reforming the system of taxation of small and medium businesses. Knowledge and understanding of the pathogenesis of arterial hypertension (AH) is the basis for the appointment of antihypertensive therapy (AHT). The prognosis of AH is directly related to the effective reduction of blood pressure (BP) to the target indicators. However, the low adherence of patients to "lifelong" therapy does not allow achieving these goals. The appointment of one drug does not always allow to reduce the BP level to the required figures, so at the moment combined AHT hIn the article the analysis of tax systems and the dynamics of small and medium business in Russia. The classification of taxes and fees, a comparison of special tax regimes: the simplified system of taxation and the single tax on imputed income. Main directions of reforming the system of taxation of small and medium businesses. Knowledge and understanding of the pathogenesis of arterial hypertension (AH) is the basis for the appointment of antihypertensive therapy (AHT). The prognosis of AH is directly related to the effective reduction of blood pressure (BP) to the target indicators. However, the low adherence of patients to "lifelong" therapy does not allow achieving these goals. The appointment of one drug does not always allow to reduce the BP level to the required figures, so at the moment combined AHT has become the leading link in the fight against AH. The use of fixed combinations "in one tablet" increases the compliance and effectiveness of therapy, thus improving the quality of life of the population. Moreover, most patients with AH require ≥2 classes of antihypertensive drugs to achieve the target blood pressure level (≤130/80 mmHg). Compared with the use of higher doses of one class of drugs, the combination of several classes of drugs works synergistically with a stronger and faster decrease in BP and fewer side effects when prescribed as initial therapy.

Keywords:blood pressure, arterial hypertension, risk of cardiovascular complications.