Some features of the immune response in herpetic keratitouveitis

Moskalets Oxana Vladimirovna

Despite numerous studies of the pathogenesis of ophthalmoherpes and the immune response to this infection, the search for rational approaches to its treatment, especially complicated forms, is still relevant. The aim of the study was to assay a number of parameters of the humoral immune response, phagocytosis, mRNA expression of some cytokines in patients with herpetic keratouveitis complicated by secondary infection, to justify the inclusion of immunotropic drugs in complex therapy. Analysis of the results revealed multidirectional changes in the studied parameters and positive clinical and laboratory dynamics in the course of treatment. Prospective observation showed that in the vast majority of cases there were no recurrences of the disease after a course of immunomodulatory therapy. The study of mRNA expression indicators is a promising method for assessing the severity of the course of herpetic keratouveitis and determining the tactics of patient management.

Keywords:ophthalmoherpes, keratouveitis, immunoglobulins, phagocytosis, mRNA, cytokines, immunotropic drugs.