Tissue-resident memory t cells in the pathogenesis and treatment of psoriasis

Lazareva P. I., Trapeznikova E. S., Stupin V. A., Silina E. V.

Psoriasis is one of the most common autoimmune diseases that mainly affects the skin. The presented review of the world literature discusses the role of tissue resident memory T-cells (TRM) in the pathogenetic pathways of development of plaque psoriasis, and potential success in finding a new effective and safe method of its treatment or improvement of existing therapies. TRMs are a pool of non-circulating lymphocytes that can reside indefinitely in peripheral tissues, including the skin in psoriasis. They can induce an adaptive immune response and, as a result, the development of psoriatic inflammation. TRMs are sources of cytokines IL-17 and IL-22, leading to the development and maintenance of psoriatic inflammation. TRMs are present and functional in psoriasis-affected areas of the skin even after complete remission of the disease. However, to date, there are no drugs that completely inhibit the pathological activity of TRM, which is presumably the main cause of the psoriasis recurrence after therapy.

Keywords:memory resident T cells, TRM, lymphocytes, cytokines, psoriasis, skin.