GENES POLYMORPHISM AND ACUTE BRONCHITIS IN CHILDREN

Pikuza Ol'ga Ivanovna, Rizvanova Farida Faritovna, Generalova Elena Vladimirovna, Kravcova Ol'ga Aleksandrovna

Objective: to study the polymorphism of pro- and anti-inflammatory interleukin genes in children with acute bronchitis. Methods: The main group included 110 children aged 6-15 years with acute bronchitis. The control group included 163 healthy schoolchildren. DNA samples for the study were obtained from peripheral venous blood and epithelial cells scraped from the oral mucosa. Results: Significant differences were revealed between the group of children with bronchitis and control group according to the TNFA gene polymorphism. Significant differences in the main group depending on age are shown: predominance of the allele (-174)G of the il6 gene (p<0.05) at the age of 6 years, and among children aged 7-11 years, the allele (-174)С the il6 gene dominated (p=0.044). In a subgroup of patients under the age of 6 years, there was a decrease in the frequency of detection of the genotype (-174)C/C the il6 gene. Conclusions: The results obtained can become the basis for determining prognostic markers of recurrence of acute bronchitis with further development of individualized treatment and prevention programs.

Keywords:children; acute bronchitis; gene polymorphism; cytokines; TNFA; IL6; IL4; IL1B