THE APPLICATION OF PLATELETE-RICH PLASMA IN THE TREATMENT OF INFERTILITY CAUSED BY ENDOMETRIAL PATHOLOGY AND REDUCED OVARIAN RESERVE

Kalimatova Donna Magomedovna, Dobrokhotova Yulia Eduardovna, Ilina Irina Yurievna

It was carried out an analysis of literature data on the use of platelet-rich plasma (PRP) to improve the effectiveness of assisted reproductive technologies (ART). It has been established that, in addition to an increased level of platelets, PRP contains a number of biologically active substances, the action of which is characterized by synergy in terms of enhancing the activity of macrophage and neutrophil cells, which contributes to the activation of angiogenesis processes, re-epithelialization, increased fibroblast activity and, as a result, tissue regeneration. To date, a number of studies have shown that PRP can be used to increase the thickness of the endometrium before embryo transfer and may increase the efficiency of implantation. The potential possibility of using PRP therapy in terms of the effect on ovarian tissue, in particular, on ovarian stem cells through the growth factors contained in PRP has been shown. It has been shown that PRP therapy with autologous preparations is characterized by high safety and minimal risk of worsening the course of diseases, immunological and/or allergic reactions during its implementation. It is concluded that, given its simplicity, the absence of serious side effects, and promising results, PRP therapy can become a new method of treatment in women with thin endometrium, repeated implantation failures, and ovarian insufficiency.

Keywords:infertility, endometrial pathology, ovarian reserve, platelet-rich plasma, growth factors, assisted reproductive technologies, thin endometrium