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CONCENTRATION OF REACTIVE OXYGEN SPECIES IN THE BIOLOGICAL ENVIRONMENT OF THE BODY DURING THIRAM FUNGICIDE INTOXICATION

Korolev V. A.  (Doct. Sci. (Biology), Professor, Head of the Department of Biology, Medical Genetics and Ecology Kursk State Medical University, Kursk, Russia)

Sedykh A. V.  (Assistant at the Department of Biology, Medical Genetics and Ecology Kursk State Medical University, Kursk, Russia)

Potenko V. V.  (Doct. Sci. (Biology), Associate Professor, Head of the Department of Biology Gomel State Medical University, Gomel, Belarus)

Felker E. V.  (Cand. Sci. (Medical), Associate Professor, Head of the Department of Orthopedic Dentistry Kursk State Medical University, Kursk, Russia)

Yachmeneva L. A.  (Assistant of the Department of Orthopedic Kursk State Medical University, Kursk, Russia)

Korolev E. V.  (Kursk State Medical University, Kursk, Russia)

The intake of thiram with food products into the tissues, organs of animals and humans can lead to the activation of free radical oxidation processes due to the accumulation of reactive oxygen species (ROS). Aim of the study: Determination of the concentration of reactive oxygen species in the biological media of the body during intoxication with the fungicide tiram. This publication investigated the effect of thiram intoxication on the quantitative content of reactive oxygen species (ROS). Modeling of subchronic intoxication was accompanied by a significant increase in the content of ROS in all analyzed body media. Thus, we have shown that the increase in the formation of free radicals occurs due to the intake of micro-amounts of the fungicide tiram into the body.

Keywords:thiram; intoxication; oxidative stress; free radicals; reactive oxygen species

 

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Citation link:
Korolev V. A., Sedykh A. V., Potenko V. V., Felker E. V., Yachmeneva L. A., Korolev E. V. CONCENTRATION OF REACTIVE OXYGEN SPECIES IN THE BIOLOGICAL ENVIRONMENT OF THE BODY DURING THIRAM FUNGICIDE INTOXICATION // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№04/2. -С. 25-28 DOI 10.37882/2223–2966.2023.04–2.15
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