SOME CYTOCHEMICAL PARAMETERS OF BLOOD NEUTROPHILS IN AUTOIMMUNE THYROIDITIS AND THYROPEROXIDASE ACTIVITY

Gorelova V. G., Osmanova A. A., Gazieva M. M., Yunusova Z. Z., Atalalieva P. G., Zeynalova G. I.

study of the activity of thyroperoxidase and cytochemical parameters of blood neutrophils in autoimmune thyroiditis (AIT) and the establishment of their possible relationships depending on the severity of the process. Material for histochemical studies were pieces of thyroid tissue taken from 27 patients with AIT after its subtotal resection. For cytochemical studies, we used venous blood taken from the same patients at admission, as well as on the 2nd and 5th days after the operation. The control was venous blood of 10 healthy volunteers aged 20-45 years. The epithelial parenchyma of the gland in hypothyroidism is gradually replaced by lymphoid infiltrates. The activity of thyroperoxidase in AIT in the phase of hypothyroidism is low and is directly dependent on the severity of the pathological process. Cytochemical parameters of neutrophils in patients with AIT with hypothyroidism syndrome are significantly increased, which is especially pronounced in the last phase of the disease.

Keywords:autoimmune thyroiditis, thyroperoxidase, neutrophils, cationic proteins