THE ROLE OF GENETIC PREDICTORS IN PREDICTING THE SEVERITY OF CROHN'S DISEASE

Danilov M. A., Chegodar A. S., Bodunova N. A., Khatkov I. E., Bykova S. V.

Crohn's disease (CD) is a chronic inflammatory bowel disease that occurs with periods of exacerbations and remissions. The etiology of CD is not fully understood. Pathogenetic mechanisms are realized as a result of the interaction of environmental factors, genetic factors, the response of the immune system and changes in the host microbiome, which leads to inflammation of the gastrointestinal mucosa. The variety of clinical manifestations, as well as extraintestinal complications, make it difficult to timely diagnose CD. The clinical picture varies depending on the degree of inflammation, severity and extent of the lesion from minimal clinical symptoms to severe, widespread transmural lesions of the digestive tube. The review presents the role of genetic predictors in the context of predisposition to CD and predicting the severity of its course.

Keywords:Crohn's disease, genetics, HLA, genetic polymorphisms