ENDOTHELIAL VASOACTIVE FACTOR GENE POLYMORPHISM AND DENTAL CARIES INTENSITY INDICATORS

Bebyakova Natalya Aleksandrovna, Levitsky Sergey Nikolaevich, Galiyeva Alexandra Sergeevna, Davydova Nadezhda Gennadyevna, Zhibort Ekaterina Leonidovna

The article presents the results of a study to reveal the relationship between the index of DMF associated with pathological processes in periodontal tissues and polymorphisms -786T>C of the NOS3 gene, Lys198Asn of the EDN1 gene, *A/A of the EDNRA gene and *G/G of the EDNRB gene in young people living in the Arctic region. A significant decrease in NO levels was observed in the *A/A polymorphic variant (rs 6842241) of the EDNRA gene. The presence of other polymorphic gene variants did not lead to significant changes in both NO and EDN1 levels. Polymorphic variants of all the genes studied in young adults were accompanied by an increase in the DMF index, but a statistically significant difference was observed only in the -786T>C variant (rs 2070774) of the NOS3 gene, which led to an increased incidence of individuals with a decompensated degree of DMF. The -786T>C polymorphism of the NOS3 gene in combination with other factors may be a risk factor for the development of dental diseases associated with disorders of vascular tone and microcirculation, including dental caries and periodontal disease.

Keywords:periodontal disease, caries intensity, peripheral vascular tone, gene polymorphism, endothelin system, endothelial NO synthase