Pozhidaev Ivan Viacheslavovich (Researcher of the Molecular Genetics and Biochemistry Laboratory, Mental Health Research Institute, Tomsk NRMC, Tomsk)
Kornetova Elena Georgievna (Doctor of Medical Sciences,
Head of the Department of Endogenous Disorders
Mental Health Research Institute, Tomsk NIMC, Tomsk
)
Ivanova Svetlana Alexandrovna (Doctor of Medical Sciences, Professor,
Head of the Laboratory of Molecular Genetics and Biochemistry,
deputy Research Director of the Mental Health Research Institute
Tomsk NIMC, Tomsk
)
| |
Tardive dyskinesia (TD) is a severe and potentially irreversible movement disorder that can develop as a side effect of long-term use of antipsychotic medications. The study studied the polymorphism of neurotransmitter genes (serotonin, muscarinic and adrenergic) receptors, which hypothetically may play a role in the development of antipsychotic-induced TD and its phenotypically different subtypes in patients with schizophrenia. It has been shown that the rs2036108 allelic variant of the ADRA1A gene is involved in the formation of the genetic component of the development of the mixed subtype of drug-induced TD in patients with schizophrenia.
Keywords:schizophrenia, mixed subtype of tardive dyskinesia, neurotransmitter receptors, gene polymorphism.
|
|
| |
|
Read the full article …
|
Citation link:
Pozhidaev I. V., Kornetova E. G., Ivanova S. A. INFLUENCE OF NEUROTRANSMISSION RECEPTOR GENE POLYMORPHISM ON THE DEVELOPMENT OF MIXED TYPE OF TARDIVE DYSKINESIA IN PATIENTS WITH SCHIZOPHRENIA // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№09/2. -С. 26-30 DOI 10.37882/2223-2966.2023.9-2.19 |
|
|
