ATRIAL FIBRILLATION IN PATIENTS WITH ABDOMINAL OBESITY IN THE PRACTICE OF A THERAPIST

Ryabaya I. N., Tarasova P. A., Filippov R. S., Kirillova E. V., Zhuravlev K. A., Goncharov V. V.

Atrial fibrillation (AF) increases the risk of cardiovascular complications and can lead to disability and death in patients. A possible predictor of the development of AF may be obesity, the prevalence of which has reached global proportions. A study was conducted on 300 people with newly diagnosed AF. The patients were divided into groups: “Abdominal obesity”, “Normal waist circumference”. It was found that in patients with abdominal obesity, the left atrial end-diastolic dimension and the prevalence of left ventricular hypertrophy were higher than in patients without abdominal obesity both at the beginning of the study and after 1 year of follow-up. The rate of recurrence of AF is significantly higher in patients with abdominal obesity than in patients with normal waist circumference. The concentration of leptin hormone in adipose tissue was studied in patients with repeated paroxysms of AF and in the group of patients without repeated paroxysms of AF; an increase in the concentration of leptin was noted in the group of patients with repeated paroxysms of AF. In the course of a multivariate analysis, predictors of repeated paroxysms of AF were identified: body mass index, diastolic blood pressure, female gender. Thus, obesity has a negative impact on cardiac remodeling and increases the prevalence of recurrent AF.

Keywords:atrial fibrillation, obesity, waist circumference, paroxysms, cardiac structural parameters, leptin