DYNAMIC MONITORING OF THE STATE OF THE VAGINAL AND INTESTINAL MICROBIOME IN WOMEN WITH A HISTORY OF UNDEVELOPED PREGNANCY

Ruhlyada Nikolaj Nikolaevich, Vinnikova Simona Viktorovna

Undeveloped pregnancy occurs in 10.0-20.0%, and in 55.6% of pregnancies at a later date, the cause is urogenital infectious diseases. The aim of our study was to evaluate the recurrence rate of vaginal and colon dysbiosis in women with a history of undeveloped pregnancy after the use of pro-, meta- and prebiotic drugs. For 12 months, the state of the vaginal and intestinal microbiome was monitored in women with a history of undeveloped pregnancy after therapy. Combination therapy (combined antimicrobial drug + combined biotic drugs) contributes to the complete elimination of dysbiosis in the studied environments. Repeated cases of dysbiotic disorders of the vaginal and intestinal microbiome were detected in 12.0% of patients with combined use of antibacterial and biotic drugs. At the same time, no recurrence of dysbiotic disorders in the studied media was detected in 68.0%.

Keywords:undeveloped pregnancy, microbiome, vagina, colon, dysbiosis.