ENDOTHELIAL DYSFUNCTION AND ITS MARKERS IN PATIENTS WITH CORONARY HEART DISEASE (CHD) WHO UNDERWENT COVID-19

Bolgov Daniil Yurievich, Kuznetsov Sergey Ivanovich, Tkachenko Maxim Sergeevich

The article presents a modern understanding of endothelial dysfunction and ways to assess it. The material characterizes the description of the role of nitric oxide and endothelin-1, as well as a number of factors synthesized by endotheliocytes, as important markers of endothelial dysfunction. The paper analyzes the dynamics of indicators characterizing endothelial disorders. The study of endothelial dysfunction in patients with coronary heart disease in the postcovid period is shown using the example of the reactive hyperemia method. The authors conclude that in order to improve the duration and quality of life of patients with coronary heart disease (CHD), in particular those who have undergone the new coronavirus infection COVID-19, reduce the risk and frequency of complications, and mortality rates, it is necessary to study the function of the endothelium in more detail. It is also necessary to look for ways to medically correct endothelial dysfunction, taking into account the pathogenetic mechanisms of its formation. The topic under consideration will be of interest to therapists, cardiologists and doctors of other related specialties. The issue of studying the mechanism of endothelial dysfunction requires further in-depth study.

Keywords:endothelial dysfunction, markers of endothelial dysfunction, endothelial damage, coronary heart disease (CHD), COVID-19.