SOLUTION OF ANTIBIOTIC RESISTANCE PROBLEMS

Reshetnik Galina Vasilyevna, Sheyko Elena Anatolyevna, Sataieva Tatiana Pavlovna, Platonova Polina Andreyevna, Gasanov Gusein Khalis

The problem of development of resistance of pathogenic microorganisms to antibiotics is one of the main problems of world medicine. Treatment of infectious diseases becomes less effective, the time of stay of patients in hospital increases, which entails the costs of treatment, and the mortality rate increases. Antibiotic resistance is characteristic of both pathogenic microorganisms and opportunistic ones. It is possible that bacterial resistance to antimicrobial drugs is dependent on excessive and uncontrolled use of antibiotics. Bacterial resistance also occurs with the acquisition of new genetic information at the level of expression of the bacterial cell's own genes, inactivation of the antibiotic by cellular enzymes, changes in the permeability of the cytoplasmic membrane, structural changes in the molecules that are targets for antibiotics, and its removal from the cell ("efflux pump") before the antibiotic can act on the cell. Scientists studying antibiotic resistance are concerned that spending on finding new antimicrobial drugs and modifying existing ones continues to decrease against the background of the growth of bacteria with multiple drug resistance.

Keywords:antibiotics, resistance, pathogenic bacteria, resistance