EXPERIMENTAL RATIONALE FOR THE USE OF INCOMPLETE SILVER SALT OF POLYACRYLIC ACID IN THE TREATMENT OF PURULENT WOUNDS IN LABORATORY ANIMALS

Netskina Anastasia Alekseevna, Zaitsev Oleg Vladimirovich, Lesovik Vasilina Sergeevna, Dumachev Alexandr Vladimirovich, Serpukhin Denis Dmitrievich

Objective: To evaluate the effect of incomplete silver salt of polyacrylic acid on the healing dynamics of purulent wounds. Methods: The study involved 70 male Soviet chinchilla rabbits (7–8 months old, 2000–3000 g). A purulent wound model was induced using a 4% fecal emulsion, followed by abscess opening. The animals were randomized into a control and an experimental group (n=35 each). The experimental group was treated with the incomplete silver salt of polyacrylic acid. Macroscopic appearance, wound area (Kundin’s formula), and exudate pH were evaluated on days 1, 5, 10, and 15. Results: By day 10, 92% of animals in the experimental group showed complete wound closure (p<0.05). Wound area reduction and pH normalization occurred significantly faster than in the control group, where healing occurred by day 15. Conclusion: The agent shows strong antiseptic, reparative, and hemostatic effects, is simple to use, does not require precise dosing, and has potential for clinical application.

Keywords:purulent wound, silver, polyacrylic acid, healing, experiment