Khokonova Tamara Muratovna (MD–PhD, Associate Professor of the Department of Microbiology, Virology and Immunology, Medical Academy of the FSBEI HE «Kabardino-Balkarian State University named after H.M. Berbekov» (KBSU))
Kharaeva Zaira Feliksovna (Doctor of Medical Sciences, Professor, Head of the Department of Microbiology, Virology and Immunology, Medical Academy of the FSBEI HE «Kabardino-Balkarian State University named after H.M. Berbekov» (KBSU))
Sokhrokova Disana Muratovna (Assistant of the Department of Microbiology, Virology and Immunology, Medical Academy of the FSBEI HE «Kabardino-Balkarian State University named after H.M. Berbekov» (KBSU))
Solyanik Svetlana Sergeevna (Senior Assistant of the Department of Pharmacy, Medical Academy of the FSBEI HE «Kabardino-Balkarian State University named after H.M. Berbekov» (KBSU))
Sokhrokova Naina Muratovna (second year resident of the specialty “Orthodontics”, Institute of Dentistry and Maxillofacial Surgery of the FSBEI HE «Kabardino-Balkarian State University named after H.M. Berbekov» (KBSU))
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This study addresses the urgent problem of cardiovascular system pathologies, which remain the leading cause of mortality. The aim of the work was to study biomarkers of N-acetyl-beta-D-glucosaminidase (NAG), tissue inhibitor of matrix proteinases-1 (TIMP-1) and proMMP1 in patients with arterial hypertension and ischemic heart disease, including cases with cardiosclerosis. The study was performed on a sample of 120 patients, distributed into 4 groups according to diagnoses, and a control group of 20 healthy individuals. The concentrations of biomarkers were determined in blood serum by enzyme immunoassay. The results demonstrated a statistically significant increase in the level of TIMP-1 in patients of all clinical groups compared with controls, as well as a significant increase in NAG in patients with CHD and postinfarction cardiosclerosis. It was found that inflammatory and cytolytic markers take part in the development of arterial hypertension, and their concentration increases with the accession of cardiovascular complications. N-acetyl-beta-D-glucosaminidase activity in dynamics reflects the degree and depth of myocardial fibrotic changes, which allows us to recommend this index as an objective biochemical test to assess the degree of cardiac damage in clinical practice.
Keywords:coronary heart disease, arterial hypertension, heart failure, cardiosclerosis, NAG, TIMP1, proMMP1.
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Citation link:
Khokonova T. M., Kharaeva Z. F., Sokhrokova D. M., Solyanik S. S., Sokhrokova N. M. PROGNOSTIC VALUE OF SERUM BIOMARKERS IN PATIENTS WITH HYPERTENSIVE AND ISCHEMIC CARDIOPATHOLOGY // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№07. -С. 249-254 DOI 10.37882/2223-2966.2025.07.38 |
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