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COMPLETE METABOLIC RESPONSE IN PRIMARY MULTIPLE CANCER AGAINST THE BACKGROUND OF COMBINATION THERAPY: THE ROLE OF SYNERGY OF IMMUNOTHERAPY, TARGETED AND CHEMOTHERAPY

Murashko Roman Alekseevich  (Doctor of Medical Sciences, chief physician of the State Budgetary Institution "Clinical Oncology Dispensary No. 1" of the Ministry of Health of the Republic of Kazakhstan, chief freelance specialist oncologist of the Ministry of Health of the Krasnodar Territory, head of the Department of Public Health and Healthcare No. 1 of the Federal State Budgetary Educational Institution of Higher Education "Kuban State Medical University" of the Ministry of Health of Russia, Krasnodar)

Makarova Yulia Mikhaylovna  (oncologist of the highest qualification category, head of the department of antitumor drug therapy No. 1 of the State Budgetary Institution “Clinical Oncology Dispensary No. 1” of the Ministry of Health of the Republic of Kazakhstan, Krasnodar)

Kozlova Anastasiya Gennadyevna  (oncologist of the second category of the department of antitumor drug therapy No. 1 of the State Budgetary Institution “Clinical Oncology Dispensary No. 1” of the Ministry of Health of the Republic of Kazakhstan, Krasnodar)

Gorkovoy Andrey Viktorovich  (Candidate of Medical Sciences, endoscopist of the highest qualification category, head of the endoscopic department of the State Budgetary Institution “Clinical Oncology Dispensary No. 1” of the Ministry of Health of the Republic of Kazakhstan, Krasnodar)

Andreev Dmitry Valerievich  (radiologist of the highest qualification category of the State Budgetary Institution “Clinical Oncology Dispensary No. 1” of the Ministry of Health of the Republic of Kazakhstan, assistant of the Department of Radiation Diagnostics No. 2 of the Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Health of Russia, Krasnodar)

The problem of primary tumor multiplicity is relevant in modern clinical oncology due to the growing number of patients with multiple malignancies. Multiple primary malignancies is a clinical situation that requires an individualized approach to treatment. The results of therapy depend on the prevalence of the process, the stage of occurrence of tumors, and the patient's reserve capabilities. The article presents a clinical case of a patient with multiple primary malignancies, including colon adenocarcinoma, large B-cell lymphoma and non-small cell lung cancer, with the achievement of a complete metabolic response against the background of combined immune-chemotherapy.

Keywords:synchronous - metachronоus primary multiple tumors; non-small cell lung cancer; colon adenocarcinoma; large-cell B-cell lymphoma; immunotherapy.

 

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Citation link:
Murashko R. A., Makarova Y. M., Kozlova A. G., Gorkovoy A. V., Andreev D. V. COMPLETE METABOLIC RESPONSE IN PRIMARY MULTIPLE CANCER AGAINST THE BACKGROUND OF COMBINATION THERAPY: THE ROLE OF SYNERGY OF IMMUNOTHERAPY, TARGETED AND CHEMOTHERAPY // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№08. -С. 185-191 DOI 10.37882/2223-2966.2025.08.17
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