NEUROINFLAMMATION IN THE PATHOGENESIS OF POST-COVID SYNDROME (LITERATURE REVIEW) PART II

Nikiforov I., Chernobrovkina T., Kostyuk G., Burigina L., Belova M., Istomina V., Kardashyan R., Igumnov S.

Neuroinflammation is a universal adaptive response of the nervous tissue to damage of any origin (infectious, mechanical, toxic, hypoxic, etc.). Its function is adaptation to damage, disruption of homeostasis and stimulation of regenerative processes. In conditions when the inflammatory reaction acquires a large scale (cytokine storm) becomes (in response to a stimulus) uncontrollable, it can itself lead to damage of the brain. In the clinical setting, it becomes relevant to control this process using biomarkers of neuroinflammation and to use their multifunctionality and multilevel interaction to enhance anti- inflammatory mechanisms.

Keywords:neuroinflammation, microglia, DAM-phenotype, cytokines, chemokines, astrogliosis, biomarkers of inflammation, proteases, glutamate, adhesion molecules.