Guliyeva Gunel Zakirkyzy (radiotherapist, Department of Proton and Photon Radiation Therapy, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation)
Mkrtchyan Liana Sirekanovna (Doctor of Medical Sciences, Head of the Rehabilitation Department of the A.F. Tsyba MRRC, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation)
Kucherov Valery Vladimirovich (Candidate of Medical Sciences, Head of the Department of X-ray Surgery at the A.F. Tsyba MRRC, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
)
Krikunova Lyudmila Ivanovna (Doctor of Medical Sciences, Professor, Chief Researcher at the Rehabilitation Department of the A.F. Tsyba MRRC, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation)
Ivanov Sergey Anatolyevich (Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Director of the Medical Radiological Research Center named after A.F. Tsyb, Peoples' Friendship University of Russia )
Kaprin Andrey Dmitrievich (Doctor of Medical Sciences, Academician of the Russian Academy of Sciences,
General Director of the NMIC of Radiology of the Ministry of Health of the Russian Federation,
Peoples' Friendship University of Russia,
P.A. Herzen Moscow Institute of Medical Sciences – branch of the Federal State Budgetary Institution "NMIC of Radiology" Ministry of Health of Russia
)
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Locally advanced cervical cancer (LACC) remains a pressing clinical problem despite the introduction of modern diagnostic and treatment methods. One of the promising technologies that can improve the effectiveness of therapy is uterine artery chemoembolization (UAC), which provides local action on the tumor with minimal systemic toxicity. Materials and methods. A retrospective and prospective study was conducted, including 108 patients with LACC stages IIA–IIIB, randomized into two groups: the main (n = 60, UAC + chemoradiotherapy — CRT) and the control (n = 48, CRT only). The effectiveness of treatment was assessed according to RECIST 1.1 criteria, and survival was analyzed using the Kaplan–Meier method. Prognostic factors and toxicity were also studied. Results. Complete tumor regression was achieved in 70.0% of patients in the CEMA+CRT group versus 38.0% in the CRT group (p = 0.001). Three-year relapse-free survival was 73.4% and 34.7%, respectively (p = 0.003), overall survival was 92.1% and 66.7% (p = 0.084). The inclusion of CEMA was accompanied by an increase in hematological toxicity (leukopenia ≥ stage II - 48% versus 2%, p < 0.001), but severe complications were rare. Significant prognostic factors were age >44 years, SCC level <5.5 ng/ml, tumor growth pattern and smoking. Conclusion. Uterine artery chemoembolization performed before CRT increases immediate and long-term efficacy of cervical cancer treatment. The method is appropriate for inclusion in clinical protocols for patients with unfavorable prognostic factors and acceptable toxicity levels.
Keywords:cervical cancer; chemoembolization, relapse-free survival, prognostic factors, SCC antigen.
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Citation link:
Guliyeva G. Z., Mkrtchyan L. S., Kucherov V. V., Krikunova L. I., Ivanov S. A., Kaprin A. D. RESULTS OF COMBINED TREATMENT OF CERVICAL CANCER WITH THE USE OF UTERINE ARTERY CHEMOEMBOLIZATION // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№10. -С. 252-258 DOI 10.37882/2223-2966.2025.10.22 |
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