Belomestnov Sergey Razumovich (MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Ural State Medical University of the Russian Ministry of Health;
Obstetrician-gynecologist, Yekaterinburg Clinical Perinatal Center, Yekaterinburg, Russia
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Pichugova Svetlana Vladimirovna (MD, PhD, Cytology and Electron Microscopy Laboratory Physician, Ya.B. Beikin Clinical and Diagnostic Center, Yekaterinburg, Russia)
Chumarnaya Tatyana Vladislavovna (MD, PhD, Biology Doctor of Medical Sciences, Senior Researcher, V.S. Markhasin Laboratory of Mathematical Physiology, Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia)
Sevostyanova Yuryevna Olga (Doctor of Medical Sciences, Professor, Department of Obstetrics and Gynecology, Ural State Medical University, Ministry of Health of the Russian Federation, Yekaterinburg, Russia)
Shchepkin Daniil Vladimirovich (Ph.D. Biologist, Senior Researcher, Head of the Laboratory of Translational Medicine and Bioinformatics, Federal State Budgetary Scientific Institution "Institute of Immunology and Physiology" of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia)
Ksenofontov Aleksey Mikhailovich (Obstetrician-gynecologist, State Budgetary Healthcare Institution of the Sverdlovsk Region "Yekaterinburg Clinical Perinatal Center", Yekaterinburg, Russia)
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The aim of this study was to investigate the inner membrane of syncytiotrophoblast mitochondria in normal pregnancy and in gestational diabetes mellitus. A total of 125 women who delivered at term were examined. The main group (103 women with gestational diabetes mellitus) was divided into two subgroups. The first subgroup included 78 women who delivered babies weighing less than 4000 grams. The second subgroup included 25 women whose newborns weighed 4000 grams or more. The control group included 22 women whose pregnancies were normal and whose newborns weighed between the 10th and 90th percentiles for gestational age. Electron microscopy of the placenta was performed, the structure of the inner membrane of syncytiotrophoblast mitochondria was assessed. Results. In the control group, a typical continuous outer membrane and an inner membrane forming cristae with minimal changes were more common. In the main group, in the second subgroup (GDM and fetal macrosomia), pronounced swelling of mitochondria, complete destruction of cristae with maximum clearing of the matrix, changes in the number of organelles, and their fusion were revealed. The proportion of placentas with signs of complete destruction of the cristae of syncytiotrophoblast mitochondria (%) in the control group was 18, in the second subgroup of the main group - 72 (p = 0.001). Conclusion. Impaired carbohydrate metabolism during pregnancy, occurring in the form of gestational diabetes mellitus, is associated with the destruction of mitochondria of syncytiotrophoblast cells. This must be taken into account when determining obstetric management, especially if a large fetus is detected.
Keywords:mitochondria, gestational diabetes mellitus, fetal macrosomia, electron microscopy, syncytiotrophoblast
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Citation link:
Belomestnov S. R., Pichugova S. V., Chumarnaya T. V., Sevostyanova Yuryevna O. , Shchepkin D. V., Ksenofontov A. M. ULTRASTRUCTURAL FEATURES OF SYNCYTIOTROPHOBLAST MITOCHORNDRIA IN GESTATIONAL DIABETES MELLITUS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№11. -С. 149-154 DOI 10.37882/2223-2966.2025.11.04 |
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