LIFESTYLE MODIFICATION AND PSYCHOEMOTIONAL STATUS CORRECTION IN PATIENTS AT HIGH RISK OF ACUTE CORONARY SYNDROME AGAINST THE BACKGROUND OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA SYNDROME

Sultanova Oksana Esedullayevna, Chernysheva Elena Nikolaevna, Chivirgina Tatyana Vyacheslavovna, Iskhakov Sultan Adygamovich, Suleymanova Zagidat Vadimovna, Sugaliyev Dauren Radmirovich

Aim of the study: To assess the impact of lifestyle modification and psycho-emotional correction on the risk of developing acute coronary syndrome (ACS) in patients with undifferentiated connective tissue dysplasia syndrome (UCTDS) who are at high risk of cardiovascular complications. Materials and methods: The study was conducted as a prospective controlled experiment involving 117 patients with high risk indicators for ACS development on the background of UCTDS. All patients underwent clinical and laboratory assessments, biochemical blood tests, and instrumental examinations. The diagnosis of UCTDS was made based on clinical guidelines, using the questionnaire by Elykumov V.A. and Kopylov A.N. The patients' anxiety levels were assessed by having participants complete the standard Spielberger-Hanin Anxiety Self-Assessment Scale. Statistical analysis of the results was performed using IBM software with STATISTICA 28.0. Results: The study confirmed the efficacy of a comprehensive program of lifestyle changes and psycho-emotional correction in patients at high risk of CVD. Over two years, participants who underwent this program showed a significant reduction in the number of acute coronary events — 6.8% compared to 14.7% in the control group, indicating a decreased risk (risk coefficient 0.46, p=0.019). Conclusion: The study demonstrated a significant reduction in anxiety and stress states among participants.

Keywords:acute coronary syndrome, connective tissue dysplasia, cardiovascular diseases, psychoemotional correction, lifestyle modification.